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Structure-activity relationship of antithrombotic polysaccharide derivatives

Franz, Gerhard and Alban, S. (1995) Structure-activity relationship of antithrombotic polysaccharide derivatives. International journal of biological macromolecules 17 (6), pp. 311-314.

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Abstract

Heparin has been the drug of choice in clinical pre-surgical and post-surgical prophylaxis of thrombotic events. However, because of its side-effects, such as bleeding and other disadvantages (i.e. chemical inhomogeneity and variability of its physiological activities), alternatives to heparin are an important field of research. A necessary procedure in the development of new drugs is the ...

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Item type:Article
Date:1995
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Franz
Identification Number:
ValueType
8789331PubMed ID
Classification:
NotationType
AnimalsMESH
Blood Coagulation TestsMESH
Dimethylformamide/pharmacologyMESH
Drug EvaluationMESH
Fibrinolytic Agents/therapeutic useMESH
Gas Chromatography-Mass SpectrometryMESH
Glucans/therapeutic useMESH
Glycosaminoglycans/physiologyMESH
Heparin/therapeutic useMESH
Heparinoids/therapeutic useMESH
HumansMESH
MethylationMESH
Molecular WeightMESH
Neovascularization, Pathologic/prevention & controlMESH
Polysaccharides/therapeutic useMESH
Structure-Activity RelationshipMESH
Sulfates/analysisMESH
Thrombosis/prevention & controlMESH
beta-GlucansMESH
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:22800
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