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Characterisation of a laminarin sulphate which inhibits basic fibroblast growth factor binding and endothelial cell proliferation

Hoffmann, R. ; Paper, D. H. ; Donaldson, J. ; Alban, S. ; Franz, Gerhard



Abstract

We have evaluated a series of laminarin sulphates with different degrees of sulphation (0.3-2.3) as antagonists of basic fibroblast growth factor (bFGF) and as inhibitors of the bFGF-dependent endothelial cell line FBHE. Inhibition of binding of bFGF by the laminarin sulphates increased with increasing degree of sulphation. Binding of bFGF to low affinity sites on BHK cells was inhibited more ...

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