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Anticoagulant and antithrombotic actions of a semisynthetic beta-1,3-glucan sulfate

Alban, S. ; Jeske, W. ; Welzel, D. ; Franz, Gerhard ; Fareed, J.


Sulfation of the natural polysaccharide curdlan results in anticoagulantly active beta-1,3-glucan sulfates whose activity depends on various structural parameters. In this study the anticoagulant and antithrombotic effects of one of these beta-1,3-glucan sulfates (GS) were compared with those of a porcine mucosal heparin. GS produced a concentration dependent anticoagulant effect in all the ...


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