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Characterization of the anticoagulant actions of a semisynthetic curdlan sulfate

Alban, S. ; Franz, Gerhard



Abstract

Sulfation of curdlan, a natural, linear beta-1,3-glucan results in potent anticoagulant and antithrombotic agents. The different activity characteristics in the classical coagulation assays were shown to depend on various structural parameters. To obtain more detailed information about their structure-dependent mechanisms of action, one representative of these beta-1,3-glucan sulfates (CurS), was ...

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