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Studies towards the total synthesis of Limnophilaspiroketone and the synthesis of alpha-modified enones of natural product derived model compound Limno-CP

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Lindner, Simon
Date of publication of this fulltext: 05 Nov 2012 07:44

Abstract (English)

Compounds with an alpha,beta-unsaturated carbonyl moiety and a phenol substituent are reported to exhibit anti-inflammatory and antioxidative activities. NF-kB and Nrf2 are important transcription factors of a complex signaling network, which mediate a multitude of different biological functions. However, they are also implicated in the pathogenesis of many inflammation-associated disorders and ...


Translation of the abstract (German)

Verbindungen mit einer alpha,beta-ungesättigten Carbonyleinheit und Phenolsubstituenten konnten anti-inflammatorische und antioxidative Eigenschaften nachgewiesen werden. NF-kB und Nrf2 sind wichtige Transkriptionsfaktoren eines komplexen Wechselspiels verschiedener Signaltransduktionswege und vermitteln eine Vielzahl von biologischen Funktionen. Sie sind jedoch auch an der Entstehung ...


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