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Evidence for de novo production of self-replicating and environmentally adapted RNA structures by bacteriophage Qbeta replicase

Sumper, Manfred and Luce, R. (1975) Evidence for de novo production of self-replicating and environmentally adapted RNA structures by bacteriophage Qbeta replicase. Proc. of the National Academy of Sciences of the USA : PNAS 72 (1), pp. 162-166.

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Date of publication of this fulltext: 13 Dec 2011 07:06

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Abstract

Highly purified coliphage Qbeta replicase when incubated without added template synthesizes self-replicating RNA species in an autocatalytic reaction. In this paper we offer strong evidence that this RNA production is directed by templates generated de novo during the lag phase. Contamination of the enzyme by traces of RNA templates was ruled out by the following experimental results: (1) ...

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Item type:Article
Date:1975
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Alumni or Retired > Prof. Dr. Manfred Sumper
Identification Number:
ValueType
5472468PubMed ID
Classification:
NotationType
Acridines/metabolismMESH
AutoradiographyMESH
Bromides/metabolismMESH
Centrifugation, Density GradientMESH
Coliphages/enzymologyMESH
DNA-Directed RNA Polymerases/metabolismMESH
ElectrophoresisMESH
Ethidium/metabolismMESH
Oligonucleotides/metabolismMESH
Phosphorus RadioisotopesMESH
RNA Viruses/enzymologyMESH
RNA, Viral/biosynthesisMESH
Ribonucleases/metabolismMESH
Templates, GeneticMESH
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:22926
Owner only: item control page

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