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Gene expression of 5-, 12-, and 15-lipoxygenases and leukotriene receptors along the rat nephron

DOI to cite this document:
10.5283/epub.23
Reinhold, Stephan W. ; Vitzthum, Helga ; Filbeck, Thomas ; Wolf, Konrad ; Lattas, Christos ; Riegger, Günter A. J. ; Kurtz, Armin ; Krämer, Bernhard K.
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Date of publication of this fulltext: 05 Aug 2009 13:21


Abstract

The arachidonate signaling pathways comprise prostanoids formed by cyclooxygenases, EETs, and HETEs formed by cytochrome P-450 (CYP) enzymes and HETEs and leukotrienes generated by lipoxygenases. Whereas the intrarenal localization of cyclooxygenases and of some CYP enzymes along the nephron has already been determined, the localization of lipoxygenases and leukotriene-forming enzymes together ...

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