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AUREMOL-QTA, a program package for NMR based automated recognition and characterization of local and global conformational changes in proteins induced by ligand binding as external perturbation

Malloni, Wilhelm Massimiliano (2013) AUREMOL-QTA, a program package for NMR based automated recognition and characterization of local and global conformational changes in proteins induced by ligand binding as external perturbation. PhD, Universität Regensburg.

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Date of publication of this fulltext: 18 Jan 2013 07:48

Abstract (English)

Among all existing techniques for protein structure determination, NMR spectroscopy has the advantage to provide the most complete characterization of molecular structures in solution. On the other hand, the low sensitivity of NMR limits the available signal-to-noise ratio. This often leads to the disappearance of cross peaks and to the misinterpretations of noise peaks as peaks originating from ...

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Translation of the abstract (German)

Unter allen existierenden Techniken zur Protein-Struktur-Bestimmung besitzt die NMR Spektroskopie den Vorteil, eine vollständige Charakterisierung der nativen molekularen Struktur der Proteine in Lösung zu bestimmen. Andererseits beschränkt die geringe Signalstärke die Empfindlichkeit der NMR und führt zu einem schlechten Signal-zu-Geräusch-Verhältnis. Das hat oft das Verschwinden von „cross ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:18 January 2013
Referee:Prof. Dr. Dr. Hans Robert Kalbitzer
Date of exam:22 December 2011
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Keywords:NMR spectroscopy, quality control, AUREMOL_QTA, structural changes, spectral changes, external perturbations, ligand binding, protein denaturation, reference and test spectra, low-level, mid-level and high level analysis, peak features, peak association, peak probabilities, missing signals
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:23196
Owner only: item control page

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