Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism

URN to cite this document:: urn:nbn:de:bvb:355-epub-232194
DOI to cite this document:: 10.5283/epub.23219

Ervens, J. ; Seifert, Roland

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Date of publication of this fulltext: 24 Jan 2012 07:55

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Abstract

3-Morpholino-sydnonimine (SIN-1) is a NO-releasing compound which mimics the effects of cGMP through activation of soluble guanylyl cyclase. Its prodrug, molsidomine (SIN-10), does not release NO but does modulate various cell functions. These findings prompted us to study the effects of SIN-10 and SIN-1 on the respiratory burst in human neutrophils. SIN-10 was more effective than SIN-1 in ...