Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides

URN to cite this document:: urn:nbn:de:bvb:355-epub-232532
DOI to cite this document:: 10.5283/epub.23253

Seifert, Roland ; Burde, R. ; Schultz, Günter

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Date of publication of this fulltext: 24 Jan 2012 13:28

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Abstract

Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe). In dibutyryl cyclic AMP-differentiated HL-60 cells, ATP and UTP in the presence of cytochalasin B activated O2- formation with EC50 values of 5 microM and efficacies amounting to ...