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The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides

Seifert, Roland, Rosenthal, W., Schultz, Günter, Wieland, T., Gierschick, P. and Jakobs, K. H. (1988) The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides. European journal of biochemistry / FEBS 175 (1), pp. 51-55.

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Abstract

NADPH-oxidase-catalyzed superoxide (O2-) formation in membranes of HL-60 leukemic cells was activated by arachidonic acid in the presence of Mg2+ and HL-60 cytosol. The GTP analogues, guanosine 5'-[gamma-thio]triphosphate (GTP[gamma S] and guanosine 5'-[beta,gamma-imido]triphosphate, being potent activators of guanine-nucleotide-binding proteins (G proteins), stimulated O2- formation up to ...

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Item type:Article
Date:1988
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
2841126PubMed ID
Classification:
NotationType
Adenine Nucleotides/pharmacologyMESH
Adenosine Triphosphate/pharmacologyMESH
Arachidonic AcidMESH
Arachidonic Acids/pharmacologyMESH
Cell LineMESH
GTP-Binding Proteins/metabolismMESH
Guanine Nucleotides/pharmacologyMESH
Guanosine 5'-O-(3-Thiotriphosphate)MESH
Guanosine Diphosphate/pharmacologyMESH
Guanosine Triphosphate/pharmacologyMESH
HumansMESH
Leukemia, Myeloid, Acute/metabolismMESH
NADH, NADPH Oxidoreductases/metabolismMESH
NADPH OxidaseMESH
Phosphotransferases/metabolismMESH
Superoxides/metabolismMESH
Thionucleotides/pharmacologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:23267
Owner only: item control page

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