Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase

URN to cite this document:: urn:nbn:de:bvb:355-epub-232686
DOI to cite this document:: 10.5283/epub.23268

Seifert, Roland ; Schächtele, C.

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Date of publication of this fulltext: 26 Jan 2012 08:33

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Abstract

The effects of various protein kinase C (PKC) inhibitors on NADPH oxidase (NO) activation by the phorbol ester PMA and by the chemotactic peptide FMLP were studied. H-7 reduced the effects of both stimuli in human neutrophils (HN) and HL-60 cells by 13-63%. Polymyxin B did not inhibit NO activation by PMA and FMLP in HN and reduced the effects of both stimuli in HL-60 cells by 27-55%. Retinal and ...