N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions

URN to cite this document:: urn:nbn:de:bvb:355-epub-233002
DOI to cite this document:: 10.5283/epub.23300

Wenzel-Seifert, K. ; Schächtele, C. ; Seifert, Roland

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Date of publication of this fulltext: 26 Jan 2012 08:21

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Abstract

The role of protein kinase C (PKC) isoenzymes in the regulation of cell functions is largely unknown. We studied the effects of 2-(1H-indol-3-yl)-3- [1-(3-dimethylaminopropyl)-1H-indol-3-yl]-maleinimide (Gö 6850), a selective inhibitor of c- and n-PKC isoenzymes, and 12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2 ,3- a]pyrrolo[3, 4-c]-carbazole (Gö 6976), an inhibitor of c-PKC ...