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The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes

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Seifert, Roland ; Hagelüken, A. ; Höer, A. ; Höer, D. ; Grünbaum, L. ; Offermanns, S. ; Schwaner, I. ; Zingel, V. ; Schunack, W. ; Schultz, Günter
Date of publication of this fulltext: 26 Jan 2012 08:19


In dibutyryl-cAMP-differentiated HL-60 cells, histamine H1 and formyl peptide receptors mediate increases in the cytosolic Ca2+ concentration ([Ca2+]i) via pertussis toxin-sensitive G proteins of the Gi family. We compared the effects of 2-(3-chlorophenyl)-histamine (CPH) [2-[2-(3-chlorophenyl)-1H-imidazol-4-yl] ethanamine], one of the most potent and selective H1 receptor agonists presently ...


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