Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants

URN to cite this document:: urn:nbn:de:bvb:355-epub-233058

Klinker, J. F. ; Schwaner, I. ; Offermanns, S. ; Hagelüken, A. ; Seifert, Roland

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Date of publication of this fulltext: 26 Jan 2012 08:27

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Abstract

Dibutyryl cAMP-differentiated HL-60 human leukemia cells possess receptors for the chemoattractants N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), C5a and leukotriene B4 (LTB4). We compared the effects of these chemoattractants in HL-60 membranes and in intact HL-60 cells. fMLP, C5a and LTB4 stimulated GTP hydrolysis and guanosine 5'-O-[3-thio]triphosphate (GTP[gamma S]) binding in HL-60 ...