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Mastoparan may activate GTP hydrolysis by Gi-proteins in HL-60 membranes indirectly through interaction with nucleoside diphosphate kinase

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Klinker, J. F. ; Hagelüken, A. ; Grünbaum, L. ; Heilmann, I. ; Nürnberg, B. ; Harhammer, R. ; Offermanns, S. ; Schwaner, I. ; Ervens, J. ; Wenzel-Seifert, K. ; Müller, T. ; Seifert, Roland
Date of publication of this fulltext: 26 Jan 2012 08:28


The wasp venom, mastoparan (MP), activates reconstituted pertussis toxin (PTX)-sensitive G-proteins in a receptor-independent manner. We studied the effects of MP and its analogue, mastoparan 7 (MP 7), on G-protein activation in HL-60 cells and a reconstituted system and on nucleoside diphosphate kinase (NDPK)-catalysed GTP formation. MP activated high-affinity GTP hydrolysis in HL-60 membranes ...


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