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Nonspecific Cation Current Associated with Native Polycystin-2 in HEK-293 Cells

Pelucchi, Bruna, Aguiari, Gianluca, Pignatelli, Angela, Manzati, Elisa, Witzgall, Ralph, Senno, Laura del and Belluzzi, Ottorino (2006) Nonspecific Cation Current Associated with Native Polycystin-2 in HEK-293 Cells. Journal of the American Society of Nephrology - JASN 17 (2), pp. 388-397.

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Other URL: http://jasn.asnjournals.org/cgi/content/abstract/17/2/388


Abstract

Mutations in either PKD1 or PKD2 gene are associated with autosomal dominant polycystic kidney disease, the most common inherited kidney disorder. Polycystin-2 (PC2), the PKD2 gene product, and the related protein polycystin-L, function as Ca2+-permeable, nonselective cation channels in different expression systems. This work describes a nonspecific cation current (ICC) that is present in native ...

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Item type:Article
Date:2006
Institutions:Biology, Preclinical Medicine > Institut für Anatomie
Identification Number:
ValueType
10.1681/ASN.2004121146DOI
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:234
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