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Nonspecific Cation Current Associated with Native Polycystin-2 in HEK-293 Cells

Pelucchi, Bruna ; Aguiari, Gianluca ; Pignatelli, Angela ; Manzati, Elisa ; Witzgall, Ralph ; Senno, Laura del ; Belluzzi, Ottorino


Mutations in either PKD1 or PKD2 gene are associated with autosomal dominant polycystic kidney disease, the most common inherited kidney disorder. Polycystin-2 (PC2), the PKD2 gene product, and the related protein polycystin-L, function as Ca2+-permeable, nonselective cation channels in different expression systems. This work describes a nonspecific cation current (ICC) that is present in native ...


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