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Potent and selective ABCG2 inhibitors derived from tariquidar

URN to cite this document:
urn:nbn:de:bvb:355-epub-235280
Ochoa Puentes, Cristian
Date of publication of this fulltext: 11 Apr 2013 15:39


Abstract (English)

Three different classes of selective ABCG2 modulator (BCRP, breast cancer resistance protein) derived from the lead structure tariquidar have been prepared in this thesis. In chapters one and two the solid phase synthesis approach was used to obtain new derivatives of the lead structure and two different methodologies were developed. A very simple, effective and straightforward method of ...

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Translation of the abstract (German)

In dieser Arbeit wurden ausgehend von Tariquidar (Leitstruktur) drei verschiedene Klassen von ABCG2 selektiven Modulatoren (BCRP, breast cancer resistance protein) erhalten. Kapitel 1 und 2 beschreiben die Entwicklung von zwei verschiedenen Methoden an Festphasensystemen, welche anschließend zur Synthese von neuen Derivaten der Leitstruktur eingesetzt wurden. Kapitel 1 beschäftigt sich mit einer ...

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