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Potent and selective ABCG2 inhibitors derived from tariquidar

Ochoa Puentes, Cristian (2013) Potent and selective ABCG2 inhibitors derived from tariquidar. PhD, Universität Regensburg.

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Date of publication of this fulltext: 11 Apr 2013 15:39

Abstract (English)

Three different classes of selective ABCG2 modulator (BCRP, breast cancer resistance protein) derived from the lead structure tariquidar have been prepared in this thesis. In chapters one and two the solid phase synthesis approach was used to obtain new derivatives of the lead structure and two different methodologies were developed. A very simple, effective and straightforward method of ...


Translation of the abstract (German)

In dieser Arbeit wurden ausgehend von Tariquidar (Leitstruktur) drei verschiedene Klassen von ABCG2 selektiven Modulatoren (BCRP, breast cancer resistance protein) erhalten. Kapitel 1 und 2 beschreiben die Entwicklung von zwei verschiedenen Methoden an Festphasensystemen, welche anschließend zur Synthese von neuen Derivaten der Leitstruktur eingesetzt wurden. Kapitel 1 beschäftigt sich mit einer ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:11 April 2013
Referee:Prof. Dr. Burkhard König
Date of exam:30 March 2012
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Keywords:Tariquidar, Elaquidar, ABCG2, Hoechst 33342 assay
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:23528
Owner only: item control page


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