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Eplerenone prevents salt-induced vascular stiffness in Zucker diabetic fatty rats: a preliminary report

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Resch, Markus ; Schmid, Peter M. ; Amann, Kerstin ; Fredersdorf, Sabine ; Weil, Joachim ; Schach, Christian ; Birner, Christoph ; Griese, Daniel P. ; Kreuzer, Peter M. ; Brunner, Sabine ; Luchner, Andreas ; Riegger, Günter A. J. ; Endemann, Dierk H.
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 11 Apr 2012 09:12


Background Aldosterone levels are elevated in a rat model of type 2 diabetes mellitus, the Zucker Diabetic fatty rat (ZDF). Moreover blood pressure in ZDF rats is salt-sensitive. The aim of this study was to examine the effect of the aldosterone antagonist eplerenone on structural and mechanical properties of resistance arteries of ZDF-rats on normal and high-salt diet. Methods After the ...


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