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Altering an Artificial Gagpolnef Polyprotein and Mode of ENV Co-Administration Affects the Immunogenicity of a Clade C HIV DNA Vaccine

Böckl, Katharina, Wild, Jens, Bredl, Simon, Kindsmüller, Kathrin, Köstler, Josef and Wagner, Ralf (2012) Altering an Artificial Gagpolnef Polyprotein and Mode of ENV Co-Administration Affects the Immunogenicity of a Clade C HIV DNA Vaccine. PLoS One 7, e34723.

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Date of publication of this fulltext: 12 Apr 2012 11:08

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Abstract

HIV-1 candidate vaccines expressing an artificial polyprotein comprising Gag, Pol and Nef (GPN) and a secreted envelope protein (Env) were shown in recent Phase I/II clinical trials to induce high levels of polyfunctional T cell responses; however, Env-specific responses clearly exceeded those against Gag. Here, we assess the impact of the GPN immunogen design and variations in the formulation ...

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Item type:Article
Date:11 April 2012
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0034723DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:23789
Owner only: item control page

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