Altering an Artificial Gagpolnef Polyprotein and Mode of ENV Co-Administration Affects the Immunogenicity of a Clade C HIV DNA Vaccine

URN to cite this document:: urn:nbn:de:bvb:355-epub-237897
DOI to cite this document:: 10.5283/epub.23789

Böckl, Katharina ; Wild, Jens ; Bredl, Simon ; Kindsmüller, Kathrin ; Köstler, Josef ; Wagner, Ralf

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Date of publication of this fulltext: 12 Apr 2012 11:08

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Abstract

HIV-1 candidate vaccines expressing an artificial polyprotein comprising Gag, Pol and Nef (GPN) and a secreted envelope protein (Env) were shown in recent Phase I/II clinical trials to induce high levels of polyfunctional T cell responses; however, Env-specific responses clearly exceeded those against Gag. Here, we assess the impact of the GPN immunogen design and variations in the formulation ...