We report on the direct observations of the effect of quantum confinement of surface-state electrons on atomic diffusion. Confined electronic states induced by open nanoscale resonators [consisting of two parallel monatomic Cu chains on Cu(111)] are studied by means of scanning tunneling microscope measurements and first-principles calculations. Strongly anisotropic diffusion of adatoms around and inside resonators is revealed at low temperatures. The formation of diffusion channels and empty zones is demonstrated. We show that it is possible to engineer atomic diffusion by varying the distance between the resonator walls.