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Untersuchung der Mechanismen, über die das Chemokin Monocyte chemoattractant protein-1 die Differenzierung von intestinalen Makrophagen verhindert

Zeitler, Katharina (2012) Untersuchung der Mechanismen, über die das Chemokin Monocyte chemoattractant protein-1 die Differenzierung von intestinalen Makrophagen verhindert. PhD, Universität Regensburg.

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Date of publication of this fulltext: 25 Jun 2012 09:54

Abstract (German)

Intestinale Makrophagen(IMAC) durchlaufen in nicht entzündeter Darmmukosa während ihrer Differenzierung einen komplexen Prozess mit Entwicklung eines anergen Phänotyps. Untersuchungen zeigten eine erhöhte Sekretion des Chemokins Monocyte chemoattractant protein-1(MCP-1) durch Epithelzellen in der Mukosa von Patienten mit chronisch entzündlichen Darmerkrankungen. Spoettl et al konnte bereits eine ...

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Translation of the abstract (English)

Intestinal macrophages (IMAC) in non-inflamed intestinal mucosa undergo a complex process of differentiation resulting in a non-reactive phenotype. Analysis showed that in mucosa of patients with inflammatory bowel disease (IBD) increased levels of monocyte chemoattractant protein-1 (MCP-1) is found. Spoettl et al could demonstrate that MCP-1 induces migration of monocytes into three-dimensional ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:25 June 2012
Referee:Prof. Dr. med Bernd Salzberger and Prof. Dr. med Matthias Edinger
Date of exam:18 April 2012
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Keywords:chronisch-entzündliche Darmerkrankung, Monocyte chemoattractant protein-1, intestinale Makrophagen
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:24939
Owner only: item control page

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