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Improving the biocompatibility of titanium- and cobalt-based biomaterials by covalent immobilization of crosslinked collagen

Müller, Rainer ; Heckmann, Klaus ; Angele, Peter ; Kujat, R. ; Nerlich, Michael


The surfaces of titanium- and cobalt-based biomaterials with layers of fibrillar type-I collagen were coated to enhance initial osteoblast adhesion and implant-tissue integration. The coating procedure for biofunctionalization of metallic implant materials was presented. Surface d. of amino groups was elevated which resulted to a higher d. of covalent linkages which improved the stability of ...


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