Novel Bis(oxazole) Pincer Ligands for Catalysis: Application in Suzuki-Miyaura Cross Coupling Reactions under Aerobic Conditions

Abstract

Introducing bis(oxazole) ligands to catalysis: novel bis(oxazole) ligands could be readily synthesized from isophthaloyl dichlorides and ethyl glycinate hydrochlorides or 6-aminoacetophenone hydrochloride. Their corresponding pincer palladium complexes proved to be extremely robust catalysts for Suzuki-Miyaura cross coupling reactions, allowing the synthesis of biaryls under aerobic conditions with turn over numbers of up to
790,000 and turn over frequencies of up to 49,000 h−1.