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Die Rolle des Zellproliferationsproteins Cdc123 bei der Initiation der Translation

Perzlmaier, Angelika (2013) Die Rolle des Zellproliferationsproteins Cdc123 bei der Initiation der Translation. PhD, Universität Regensburg.

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Date of publication of this fulltext: 16 Aug 2013 15:11

Abstract (German)

Das eukaryotische Protein Cdc123 wurde ursprünglich als Zellproliferationsfaktor identifiziert, welcher essentiell für den Übergang von der G1- in die S-Phase des Zellzyklus ist. Weitere Untersuchungen in der Bäckerhefe Saccharomyces cerevisiae brachten Cdc123 mit der Initiation der Translation, insbesondere mit der γ-Untereinheit des heterotrimeren Initiationsfaktors eIF2, in Verbindung. Die ...

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Translation of the abstract (English)

The conserved eukaryotic protein Cdc123 was first identified as a cell proliferation factor involved in the G1/S transition of the cell cycle. Studies in Saccharomyces cerevisiae (budding yeast) then linked Cdc123 to translation initiation, particularly to the γ-subunit of the heterotrimeric translation initiation factor eIF2. eIF2 recruits the initiator-tRNA for translation initiation and is a ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:16 August 2013
Referee:Prof. Dr. Wolfgang Seufert
Date of exam:15 February 2012
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Cell Cycle Control > Prof. Dr. Wolfgang Seufert
Keywords:Saccharomyces cerevisiae, Cdc123 (cell division cycle 123), eIF2 (eukaryotic initiation factor 2), budding yeast, Bäckerhefe, translation initiation, Translationsinitiation
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:25350
Owner only: item control page

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