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Endogenously expressed bestrophin-1 modulates calcium signaling in the retinal pigmented epithelium

Más Gómez, Néstor (2012) Endogenously expressed bestrophin-1 modulates calcium signaling in the retinal pigmented epithelium. PhD, Universität Regensburg.

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Date of publication of this fulltext: 16 Aug 2012 12:20

Abstract (English)

Mutations in the BEST1 gene lead to a variety of retinal degenerations. To understand the function of the BEST1 gene product, bestrophin-1, represents the first step in the investigation of patho-mechanisms leading to BEST1-associated retinal degenerations. Bestrophin-1 is a protein expressed in the cells of the retinal pigment epithelium (RPE), a monolayer of epithelial cells in the outer retina ...


Translation of the abstract (German)

Mutationen im BEST1-Gen führen zu einer Vielfalt retinaler Degenerationen. Ein Verständnis der Funktion des BEST1-Genprodukts, Bestrophin-1, stellt den ersten Schritt in Untersuchungen zum Pathomechanismus BEST1-assoziierter Retinadegenerationen dar. Bestrophin-1-Protein ist im Retinalen Pigmentepithel, einem einschichtigen Epithelium der äußeren Retina, welches eng mit den Photorezeptoren ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:16 August 2012
Referee:Prof. Dr. Olaf Strauß
Date of exam:12 July 2012
Institutions:Medicine > Lehrstuhl für Augenheilkunde
Interdisciplinary Subject Network:Not selected
Keywords:Bestrophin-1, endoplasmic reticulum, store-operated calcium entry
Dewey Decimal Classification:500 Science > 570 Life sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:25479
Owner only: item control page


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