Synthesis of Pyrimidopyrimidinediones in a Deep Eutectic
Reaction Mixture

Abstract

An efficient and general synthesis of hexahydropyrimidopyrimidinediones has been developed employing a low melting L-(+)-tartaric acid-dimethylurea mixture as reaction medium. The melt acts at the same time as solvent, catalyst and reactant. Functionalized hexahydropyrimidopyrimidinediones are obtained in good to excellent yields after simple work-up.