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Synthesis of Pyrimidopyrimidinediones in a Deep Eutectic
Reaction Mixture

Gore, Sangram ; Baskaran, Sundarababu ; König, Burkhard


An efficient and general synthesis of hexahydropyrimidopyrimidinediones has been developed
employing a low melting l-(+)-tartaric cid-dimethylurea mixture as reaction medium. The melt acts at the same time as solvent, catalyst and reactant. Functionalized hexahydropyrimidopyrimidinediones are obtained in good to excellent yields after simple work-up.

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