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Isoflurane Induces Endothelial Apoptosis of the Post-Hypoxic Blood-Brain Barrier in a Transdifferentiated Human Umbilical Vein Edothelial Cell Model

URN to cite this document:
urn:nbn:de:bvb:355-epub-258344
Dittmar, Michael S. ; Petermichl, Walter ; Schlachetzki, Felix ; Graf, Bernhard M. ; Gruber, Michael
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Date of publication of this fulltext: 07 Sep 2012 06:59


Abstract

Isoflurane is a popular volatile anesthetic agent used in humans as well as in experimental animal research. In previous animal studies of the blood-brain barrier (BBB), observations towards an increased permeability after exposure to isoflurane are reported. In this study we investigated the effect of a 2-hour isoflurane exposure on apoptosis of the cerebral endothelium following 24 hours of ...

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