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Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data

Fredersdorf, Sabine, Thumann, Christian, Zimmermann, Wolfram H., Vetter, Roland, Graf, Tobias, Luchner, Andreas, Riegger, Günter A. J., Schunkert, Heribert, Eschenhagen, Thomas and Weil, Joachim (2012) Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data. Cardiovascular Diabetology 11, p. 57.

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Date of publication of this fulltext: 07 Sep 2012 07:00

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Abstract

Background Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins). Methods Zucker Diabetic Fatty rats treated with or without insulin (ZDF +/- Ins, n = 13) and lean littermates (controls, n = 7) were sacrificed at the age of 19 weeks. ZDF ...

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Item type:Article
Date:23 May 2012
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/1475-2840-11-57DOI
Keywords:Diabetic heart; Insulin; SERCA expression; Relaxation velocity
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:25840
Owner only: item control page

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