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Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data

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Fredersdorf, Sabine ; Thumann, Christian ; Zimmermann, Wolfram H. ; Vetter, Roland ; Graf, Tobias ; Luchner, Andreas ; Riegger, Günter A. J. ; Schunkert, Heribert ; Eschenhagen, Thomas ; Weil, Joachim
License: Creative Commons Attribution 3.0
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Date of publication of this fulltext: 07 Sep 2012 07:00


Background Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins). Methods Zucker Diabetic Fatty rats treated with or without insulin (ZDF +/- Ins, n = 13) and lean littermates (controls, n = 7) were sacrificed at the age of 19 weeks. ZDF ...


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