Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1;2/TNF

URN to cite this document:: urn:nbn:de:bvb:355-epub-258424
DOI to cite this document:: 10.5283/epub.25842

Haas, Stefanie ; Straub, Rainer H.

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Date of publication of this fulltext: 07 Sep 2012 07:04

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Abstract

Introduction Circadian rhythms play an important role in the body and in single cells. Rhythms of molecular clocks have not been investigated in synovial fibroblasts (SF) of patients with osteoarthritis (OA) and rheumatoid arthritis (RA). The study was initiated to fill this gap and to study effects of interleukin (IL)-1β/tumor necrosis factor (TNF) on rhythmicity in synovial fibroblasts of RA ...