An Early Reduction in Treg Cells Correlates with Enhanced Local Inflammation in Cutaneous Leishmaniasis in CCR6-Deficient Mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-260177
DOI to cite this document:: 10.5283/epub.26017

Barth, Thomas ; Schmidt, Dominic ; Botteron, Catherine ; Nguyen, Trang T. T. ; Ritter, Uwe ; Männel, Daniela N. ; Lechner, Anja

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Date of publication of this fulltext: 09 Oct 2012 11:56

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Abstract

Resistance to Leishmania major infection is dependent on the development of a cell-mediated Th1 immune response in resistant C57BL/6 mice whereas Th2-prone BALB/c mice develop non-healing lesions after infection. The chemokine receptor CCR6 is shared by anti-inflammatory regulatory T cells and pro-inflammatory Th17 cells. In a recent study we showed that C57BL/6 mice deficient in CCR6 exhibited ...