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Mesenchymal stem cell-educated Macrophages

URN to cite this document:
urn:nbn:de:bvb:355-epub-260830
Eggenhofer, Elke ; Hoogduijn, Martin J.
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Date of publication of this fulltext: 23 Oct 2012 06:38


Abstract

Mesenchymal stem cells (MSC) mediate their immunosuppressive effects via a variety of mechanisms. One of these mechanisms involves the induction of macrophages with immunomodulatory capacities. This effect of MSC may be exploited when MSC are used as a cell therapeutic product. Furthermore, MSC are resident in tissues where they may locally target infiltrating macrophages to adapt more regulatory ...

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