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The absorption of xanthohumol in in vitro and in vivo studies and the investigation of the biological activity of structurally related chalcones

Motyl, Magdalena (2013) The absorption of xanthohumol in in vitro and in vivo studies and the investigation of the biological activity of structurally related chalcones. PhD, Universität Regensburg.

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Date of publication of this fulltext: 16 Jan 2013 07:47

Abstract (English)

XN is an abundant chalcone in hops and spread a wide range of pharmacological effects. The lipophilicity of XN is a challenge for water based in vitro studies. For this reason suitable experimental set ups for in vitro experiments were established. A content of 10% FCS in the cell culture medium was found to efficiently increase the solubility of XN. However the application of 10% FCS did not ...

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Translation of the abstract (German)

Xanthohumol (XN) gehört zu der Gruppe der Chalkone und ist ein zentraler Bestandteil im Hopfen. XN hat vielfältige pharmakologische Effekte. Die Lipophilie von XN ist eine Herausforderung für in vitro Studien in wässrigen Systemen. Aus diesem Grund wurde ein Schwerpunkt dieser Arbeit auf die Entwicklung geeigneter analytischer Verfahren gelegt. Es konnte gezeigt werden, dass der Zusatz von 10 % ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:16 January 2013
Referee:Prof. Dr. Jörg Heilmann
Date of exam:26 October 2012
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Keywords:Xanthohumol, Chalcone, absorption, in vivo studies, in vitro studies
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:26572
Owner only: item control page

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