Skin tissue fluid levels of cefotiam in healthy man following oral cefotiam hexetil

URN to cite this document:: urn:nbn:de:bvb:355-epub-268344
DOI to cite this document:: 10.5283/epub.26834

Korting, H. C. ; Schäfer-Korting, M. ; Kees, Frieder K. ; Lukacs, A. ; Grobecker, H.

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Date of publication of this fulltext: 30 Nov 2012 07:19

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Abstract

Cefotiam hexetil is a pro-drug of cefotiam available for oral administration. To evaluate cefotiam concentrations at the active site in skin and soft-tissue infections, drug levels in skin suction blister fluid (SBF), cantharides blister fluid (CBF) and serum were determined. Six healthy subjects received oral cefotiam 400 mg as cefotiam hexetil. On an other day 200 mg was injected intravenously. ...