Elektronenmikroskopische und inununhistochemische Untersuchungenzur augendrucksenkenden Wirkung von Prostaglandin F2alpha [Electron microscopy and immunohistochemical studies of the intraocular pressure lowering effect of prostaglandin F2 alpha]

URN to cite this document:

urn:nbn:de:bvb:355-epub-268734 Copy

DOI to cite this document:

10.5283/epub.26873 Copy

Tamm, Ernst R. ; Rittig, M. ; Lütjen-Drecoll, E.

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Date of publication of this fulltext: 04 Dec 2012 07:18

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Details

Item type:	Article
Journal or Publication Title:	Fortschritte der Ophthalmologie
Publisher:	Springer
Volume:	87
Number of Issue or Book Chapter:	6
Page Range:	pp. 623-629
Date:	1990
Institutions:	Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm
Identification Number:	Value Type 2086407 PubMed ID
Classification:	Notation Type Animals MESH Ciliary Body/drug effects MESH Collagen/analysis MESH Dinoprost/pharmacology MESH Immunohistochemistry MESH Intraocular Pressure/drug effects MESH Laminin/analysis MESH Macaca fascicularis MESH Microscopy, Electron MESH
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	26873

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Abstract

Topically applied prostaglandin F2 alpha (PGF2 alpha) has been shown to lower intraocular pressure in cynomolgus monkeys. In this study the morphological changes following topical treatment of seven cynomolgus monkeys with 4 micrograms PGF2 alpha isopropylester for 5-8 days were investigated and compared with the eyes of five normal animals. Quantitative light microscopical, ultrastructural and ...

Abstract

Topically applied prostaglandin F2 alpha (PGF2 alpha) has been shown to lower intraocular pressure in cynomolgus monkeys. In this study the morphological changes following topical treatment of seven cynomolgus monkeys with 4 micrograms PGF2 alpha isopropylester for 5-8 days were investigated and compared with the eyes of five normal animals. Quantitative light microscopical, ultrastructural and immunhistochemical methods were used. No cellular signs of inflammation were seen in any of the eyes. Slight edema in the most anterior part of the ciliary processes occurred in most eyes, but only in parts of the circumference. The most pronounced change was dilation of the intramuscular spaces within the ciliary muscle. No changes were observed in the extracellular matrix within the muscle bundles, which consist partly of type IV and VI collagen, laminin and fibronectin. In the connective tissue between the muscle bundles, loss of collagen type I and III fibrils was observed. Additionally, macrophages were found with phagolysosomes containing phagocytized collagen fibrils. We suggest that loss of extracellular material leads to a widening of the uveoscleral outflow pathways of ciliary muscle and thereby to a reduction in intraocular pressure.

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