Immunzytochemische und ultrastrukturelle Untersuchungen am menschlichen Skleralsporn. Charakterisierung einer kontraktilen Zellpopulation [Immunocytochemical and ultrastructural studies of human scleral spur. Characterization of a contractile cell population]

URN zum Zitieren dieses Dokuments:

urn:nbn:de:bvb:355-epub-268836 Copy

DOI zum Zitieren dieses Dokuments:

10.5283/epub.26883 Copy

Tamm, Ernst R. ; Flügel, C. ; Stefani, F. H. ; Rohen, J. W.

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Veröffentlichungsdatum dieses Volltextes: 04 Dez 2012 07:13

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Alternative Links zum Volltext:Pubmed

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Details

Dokumentenart:	Artikel
Titel eines Journals oder einer Zeitschrift:	Der Ophthalmologe
Verlag:	Springer
Band:	90
Nummer des Zeitschriftenheftes oder des Kapitels:	1
Seitenbereich:	S. 66-72
Datum:	1993
Institutionen:	Biologie und Vorklinische Medizin > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm
Identifikationsnummer:	Wert Typ 8443454 PubMed-ID
Klassifikation:	Notation Art Adolescent MESH Adult MESH Aged MESH Aged, 80 and over MESH Choroid Neoplasms/pathology MESH Ciliary Body/pathology MESH Contractile Proteins/analysis MESH Female MESH Fluorescent Antibody Technique MESH Humans MESH Male MESH Melanoma/pathology MESH Microscopy, Electron MESH Middle Aged MESH Sclera/pathology MESH Trabecular Meshwork/pathology MESH
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Unbekannt / Keine Angabe
Dokumenten-ID:	26883

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Zusammenfassung

Contraction of the ciliary muscle induced by cholinergic drugs causes movement of the scleral spur and separation of the trabecular meshwork lamellae. The effect of epinephrine, however, does not seem to be mediated by ciliary muscle tone. We investigated the scleral spur in 37 human eyes (age 17-87 years). Serial tangential sections were studied with ultrastructural and immunocytochemical ...

Zusammenfassung

Contraction of the ciliary muscle induced by cholinergic drugs causes movement of the scleral spur and separation of the trabecular meshwork lamellae. The effect of epinephrine, however, does not seem to be mediated by ciliary muscle tone. We investigated the scleral spur in 37 human eyes (age 17-87 years). Serial tangential sections were studied with ultrastructural and immunocytochemical methods. The ciliary muscle cells do not enter the scleral spur, but their tendons, which consist of elastic fibers, are continuous with the elastic fibers in the scleral spur. Within the scleral spur is found a population of circularly oriented and spindle-shaped cells. The scleral spur cells form no bundles, but are loosely aggregated. They have long cytoplasmic processes and are connected to each other by adherence type and gap junctions. The scleral spur cells show intense staining for smooth-muscle-specific alpha-actin and myosin. Ultrastructurally, the scleral spur cells contain abundant actin filaments, but otherwise do not show the typical ultrastructure of ciliary muscle cells. The scleral spur cells do not express a complete basal lamina. They form individual tendinous connections with the elastic fibers in the scleral spur, which are continuous with the elastic fibers of the trabecular meshwork. The scleral spur cells are in close contact with nerve terminals containing small granular vesicles that are typical for adrenergic terminals. We conclude that the scleral spur cells are contractile myofibroblasts. Their contraction might be involved in the effects of epinephrine on the aqueous outflow.

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