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Endothelium derived relaxing factor is involved in the pressure control of renin gene expression in the kidney

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Schricker, Karin ; Della Bruna, R. ; Hamann, Marlies ; Kurtz, Armin
Date of publication of this fulltext: 05 Dec 2012 10:25


To study the influence of endothelium derived relaxing factor/nitric oxide (EDNO) on renin gene expression, the effects of a 2-day treatment with the NO-synthase inhibitor nitro-L-arginine-methylester (L-NAME, 40 mg/kg twice a day) on plasma renin activity (PRA) and renal and adrenal renin m-RNA levels were examined in conscious rats with and without unilateral renal clips (0.2 mm). In ...


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