Interrelation between renin mRNA levels, renin secretion, and blood pressure in two-kidney, one clip rats

URN to cite this document:: urn:nbn:de:bvb:355-epub-269247
DOI to cite this document:: 10.5283/epub.26924

Schricker, Karin ; Holmer, S. ; Hamann, Marlies ; Riegger, G. ; Kurtz, Armin

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Date of publication of this fulltext: 05 Dec 2012 10:33

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Abstract

To examine the interrelation between renin mRNA levels, renin secretion, and blood pressure in rats, we clipped the left renal arteries of rats and measured renin mRNA levels in both kidneys, plasma renin activity, and blood pressure. One and 2 days after clipping, renin mRNA levels increased 3-fold and 4.3-fold in the stenosed kidney and were suppressed to 52% and 26% of controls in the intact ...