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Role of the macula densa in the control of renal renin gene expression in two-kidney/one-clip rats

URN to cite this document:
urn:nbn:de:bvb:355-epub-269264
Schricker, Karin ; Hamann, Marlies ; Kaissling, B. ; Kurtz, Armin
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Date of publication of this fulltext: 05 Dec 2012 10:21


Abstract

This study was designed to examine whether macula densa function is involved in the changes of renal renin gene expression upon acute hypoperfusion of one kidney. To block macula densa function, rats with free access to salt and water were subcutaneously infused with furosemide (12 mg/day) for 6 days. Then, 4 days after the start of the infusion, the left renal arteries were clipped with 0.2-mm ...

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