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Production of erythropoietin by liver cells in vivo and in vitro

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Eckardt, Kai-Uwe ; Pugh, C. W. ; Meier, M. ; Tan, C. C. ; Ratcliffe, P. J. ; Kurtz, Armin
Date of publication of this fulltext: 11 Dec 2012 08:44


Several lines of evidence indicate that the liver is the predominant production site for EPO during the early stages of development. Moreover, in adults, it may contribute significantly to EPO production in some species. Independent of age hepatocytes are the major cellular sites of EPO gene expression in the liver, but quantitatively less significant expression also occurs in at least one ...


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