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Hypoxia-induced accumulation of erythropoietin mRNA in isolated hepatocytes is inhibited by protein kinase C

Eckardt, Kai-Uwe, Ring, A., Maier, M., Gess, B., Fabbro, D. and Kurtz, Armin (1994) Hypoxia-induced accumulation of erythropoietin mRNA in isolated hepatocytes is inhibited by protein kinase C. Pflügers Archiv : European journal of physiology 426 (1-2), pp. 21-30.

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Abstract

To define the role of protein kinase C (PKC) in oxygen-dependent production of erythropoietin (EPO) in the liver, we have determined EPO messenger ribonucleic acid (mRNA) expression in primary cultures of juvenile rat hepatocytes incubated at different oxygen tensions in the absence and presence of phorbol esters, vasopressin, and structurally different kinase inhibitors. Upon reduction of oxygen ...

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Item type:Article
Date:1994
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
8146021PubMed ID
Classification:
NotationType
Alkaloids/pharmacologyMESH
AnimalsMESH
Cell Hypoxia/physiologyMESH
Diglycerides/pharmacologyMESH
Erythropoietin/metabolismMESH
Gene ExpressionMESH
Isoenzymes/metabolismMESH
Liver/metabolismMESH
MaleMESH
Phorbol Esters/pharmacologyMESH
Protein Kinase C/metabolismMESH
RNA, Messenger/metabolismMESH
RatsMESH
Rats, Sprague-DawleyMESH
Signal TransductionMESH
StaurosporineMESH
Vasopressins/pharmacologyMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:26928
Owner only: item control page

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