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Which factor mediates reno-renal control of renin gene expression?

Holmer, S., Eckardt, Kai-Uwe, Aedtner, O., LeHir, M., Schricker, K., Hamann, M., Götz, Karlheinz, Riegger, Günter A. J., Moll, Waldemar and Kurtz, Armin (1993) Which factor mediates reno-renal control of renin gene expression? Journal of hypertension 11 (10), pp. 1011-1019.

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Abstract

The results suggest that the suppression of renin gene expression in the contralateral kidneys of stenosed kidneys is not due to compensatory renal growth nor mediated by systemic blood pressure, angiotensin II AT1 receptors or renal nerves. We therefore hypothesize that kidneys with reduced perfusion release a humoral factor that acts as a potent inhibitor of renin gene expression.


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Item type:Article
Date:1993
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
8258664PubMed ID
Classification:
NotationType
Angiotensin Receptor AntagonistsMESH
AnimalsMESH
Biphenyl Compounds/pharmacologyMESH
ConstrictionMESH
DenervationMESH
Gene Expression RegulationMESH
Imidazoles/pharmacologyMESH
Kidney/physiologyMESH
LosartanMESH
MaleMESH
Nervous System Physiological PhenomenaMESH
RNA, Messenger/metabolismMESH
RatsMESH
Rats, Sprague-DawleyMESH
Renal Artery/physiologyMESH
Renal Circulation/physiologyMESH
Renin/geneticsMESH
Tetrazoles/pharmacologyMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:26931
Owner only: item control page

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