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Which factor mediates reno-renal control of renin gene expression?

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Holmer, S. ; Eckardt, Kai-Uwe ; Aedtner, O. ; LeHir, M. ; Schricker, K. ; Hamann, M. ; Götz, Karlheinz ; Riegger, Günter A. J. ; Moll, Waldemar ; Kurtz, Armin
Date of publication of this fulltext: 11 Dec 2012 08:49


The results suggest that the suppression of renin gene expression in the contralateral kidneys of stenosed kidneys is not due to compensatory renal growth nor mediated by systemic blood pressure, angiotensin II AT1 receptors or renal nerves. We therefore hypothesize that kidneys with reduced perfusion release a humoral factor that acts as a potent inhibitor of renin gene expression.

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