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Furosemide stimulates renin expression in the kidneys of salt-supplemented rats

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Modena, B. ; Holmer, S. ; Eckardt, K. U. ; Schricker, K. ; Riegger, G. ; Kaissling, B. ; Kurtz, Armin
Date of publication of this fulltext: 11 Dec 2012 08:53


This study was conducted to obtain information about a possible influence of salt transport by the thick ascending limb of Henle (TALH) and the macula densa on the expression of renin in the kidney. To this end, adult male rats were subcutaneously infused with furosemide (12 mg/24 h), an established inhibitor of TALH and macula densa salt transport, or with vehicle for 6 days. The animals had ...


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