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Liberators of NO exert a dual effect on renin secretion from isolated mouse renal juxtaglomerular cells

URN to cite this document:
urn:nbn:de:bvb:355-epub-269356
Schricker, K. ; Kurtz, Armin
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Date of publication of this fulltext: 04 Dec 2012 13:49


Abstract

This study aimed to examine the role of nitric oxide (NO) in the regulation of renin secretion from renal juxtaglomerular (JG) cells. Using primary cultures of mouse renal JG cells, we found that sodium nitroprusside (SNP) and 3-morpholino-sydnonimin-hydrochloride (SIN-1), two structurally different liberators of NO, led to a transient inhibition during the first hour followed by a marked ...

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