Go to content
UR Home

Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro

URN to cite this document:
DOI to cite this document:
Eckardt, Kai-Uwe ; Pugh, C. W. ; Ratcliffe, P. J. ; Kurtz, Armin
Date of publication of this fulltext: 05 Dec 2012 10:17


Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation. When isolated hepatocytes were incubated at reduced oxygen tensions for 18-48 h, we found increased secretion of EPO protein and elevated levels of EPO mRNA, ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons