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Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro

Eckardt, Kai-Uwe, Pugh, C. W., Ratcliffe, P. J. and Kurtz, Armin (1993) Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro. Pflügers Archiv : European journal of physiology 423 (5-6), pp. 356-364.

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Abstract

Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation. When isolated hepatocytes were incubated at reduced oxygen tensions for 18-48 h, we found increased secretion of EPO protein and elevated levels of EPO mRNA, ...

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Item type:Article
Date:1993
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
8351193PubMed ID
Classification:
NotationType
AnimalsMESH
Anoxia/metabolismMESH
Cell Survival/drug effectsMESH
Cells, CulturedMESH
CentrifugationMESH
Erythropoietin/geneticsMESH
Gene Expression Regulation/physiologyMESH
Liver/metabolismMESH
MaleMESH
Oxygen/physiologyMESH
Protein BiosynthesisMESH
Protein Synthesis Inhibitors/pharmacologyMESH
RNA, Messenger/metabolismMESH
RatsMESH
Rats, Sprague-DawleyMESH
Second Messenger Systems/drug effectsMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:26936
Owner only: item control page

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