Distribution of erythropoietin producing cells in rat kidneys during hypoxic hypoxia

URN to cite this document:: urn:nbn:de:bvb:355-epub-269388
DOI to cite this document:: 10.5283/epub.26938

Eckardt, Kai-Uwe ; Koury, S. T. ; Tan, C. C. ; Schuster, S. J. ; Kaissling, B. ; Ratcliffe, P. J. ; Kurtz, Armin

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Date of publication of this fulltext: 06 Dec 2012 13:42

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Abstract

We have used in situ hybridization to determine the localization and distribution of cells expressing the erythropoietin (EPO) gene in kidneys of rats exposed to reduced oxygen tensions to characterize the control of renal EPO formation during hypoxic hypoxia. Animals were subjected to severe hypoxia (7.5% O2) for 4, 8 and 32 hours to assess changes related to the duration of hypoxic exposure, ...