Extracellular calcium exerts a dual effect on renin secretion from isolated mouse juxtaglomerular cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-269399
DOI to cite this document:: 10.5283/epub.26939

Schricker, Karin ; Della Bruna, R. ; Kurtz, Armin

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Date of publication of this fulltext: 06 Dec 2012 13:52

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Abstract

Utilizing primary cultures of mouse renal juxtaglomerular cells we found that renin secretion during 20 h of incubation was stimulated by 100% when extracellular calcium was lowered from a basal level of 0.5 mM to below 1 microM, and was enhanced in a concentration-dependent fashion by 600% when extracellular calcium was increased up to 10 mM. The stimulatory effect of low calcium on renin ...