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Pharmacokinetics of recombinant human erythropoietin applied subcutaneously to children with chronic renal failure

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Braun, A. ; Ding, R. ; Seidel, C. ; Fies, T. ; Kurtz, Armin ; Schärer, K.
Date of publication of this fulltext: 11 Dec 2012 08:56


The single-dose pharmacokinetics of recombinant human erythropoietin (rHuEPO) given SC was investigated in 20 patients aged 7-20 years at different stages of chronic renal failure. In a pilot study we confirmed the lower bioavailability of the drug in 2 children when given SC compared with the IV route (24% and 43%, respectively). Following administration of 4,000 units/m2, rHuEPO SC effective ...


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