Increased plasma viscosity as a reason for inappropriate erythropoietin formation

URN to cite this document:: urn:nbn:de:bvb:355-epub-269428
DOI to cite this document:: 10.5283/epub.26942

Singh, A. ; Eckardt, Kai-Uwe ; Zimmermann, A. ; Götz, Karlheinz ; Hamann, M. ; Ratcliffe, P. J. ; Kurtz, Armin ; Reinhart, W. H.

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Date of publication of this fulltext: 11 Dec 2012 08:54

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Abstract

The aim of this study was to examine whether altered plasma viscosity could contribute to the inappropriately low production rate of erythropoietin (EPO) observed in patients suffering from hypergammaglobulinemias associated with multiple myeloma or Waldenström's disease. We found that the EPO formation in response to anemia in these patients was inversely related to plasma viscosity. A similar ...