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Renal innervation plays no role in oxygen-dependent control of erythropoietin mRNA levels

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Eckardt, K. U. ; LeHir, M. ; Tan, C. C. ; Ratcliffe, P. J. ; Kaissling, B. ; Kurtz, Armin
Date of publication of this fulltext: 04 Dec 2012 13:50


To assess the role of renal innervation in O2-dependent control of erythropoietin (EPO) formation, we have determined EPO mRNA levels in both kidneys of unilaterally denervated rats and sham-operated controls using RNase protection. To investigate whether possible effects of renal nerve input are related to the type of hypoxic stimulus and the degree of stimulation, animals were studied under ...


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